Ingredients | Amount Per Serving |
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Total Carbohydrates
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<1 Gram(s) |
(Niacinamide)
(Niacin (Form: as Nicotinamide) )
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156 mg |
1300 mg | |
(D-Ribose, Powder)
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Hydrogenated Palm Oil
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(Niacinamide)
(Niacin (Form: as Nicotinamide) )
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Vegetarian Capsule, Rice hull extract PlantPart: hull, Silica
Below is general information about the effectiveness of the known ingredients contained in the product NAD+. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product NAD+. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when prescription products are used orally and appropriately (12033). ...when niacinamide supplements are taken orally in doses below the tolerable upper intake level (UL) set by the Institute of Medicine (IOM). The UL of niacinamide is 30 mg daily for adults 18 years of age and 35 mg daily for adults 19 years and older (6243).
POSSIBLY SAFE ...when used orally in doses greater than 30 mg but less than 900 mg daily. The European Food Safety Authority has set the tolerable upper intake level (UL) of niacinamide at 900 mg daily (104937). However, oral niacinamide has been safely used in doses up to 1500 mg daily for 12 weeks in some clinical trials (25561,94188,98940,107709,110502). ...when used topically and appropriately for up to 12 weeks (5940,93360,110498,110501).
CHILDREN: LIKELY SAFE
when used orally and appropriately.
Niacinamide has been safely used in children for up to 7 years in doses below the tolerable upper intake level (UL) (4874,9957). The UL of niacinamide for children by age is: 1-3 years, 10 mg daily; 4-8 years, 15 mg daily; 9-13 years, 20 mg daily; 14-18 years, 30 mg daily (6243).
PREGNANCY AND LACTATION: LIKELY SAFE
when used orally in amounts that do not exceed the tolerable upper intake level (UL) for niacinamide.
The UL of niacinamide during pregnancy and lactation is 30 mg daily for those 14-18 years of age and 35 mg daily for those 19 years and older (6243). There is insufficient reliable information available about the safety of larger oral doses of niacinamide or topical niacinamide; avoid using.
LIKELY SAFE ...when used in amounts commonly found in food. Consuming ribose up to 36 mg/kg daily from food sources is considered safe by the European Food Safety Authority (103292). ...when used orally and appropriately, short-term (15218,15723,15724,15725,15726,15727,15728,15729,15730). Ribose has been used safely at doses up to 15 grams daily for up to 12 weeks (15218,15725,15727,15730,71601,100680,103291,108959). ...when used intravenously and appropriately, short-term (5662,5663,5676,5680,71603). There is insufficient reliable information available about the safety of ribose when used long-term.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product NAD+. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, niacinamide may have additive effects when used with anticoagulant or antiplatelet drugs, especially in patients on hemodialysis.
Details
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Niacinamide might increase the levels and adverse effects of carbamazepine.
Details
Plasma levels of carbamazepine were increased in two children given high-dose niacinamide, 60-80 mg/kg/day. This might be due to inhibition of the cytochrome P450 enzymes involved in carbamazepine metabolism (14506). There is not enough data to determine the clinical significance of this interaction.
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Niacinamide might increase the levels and adverse effects of primidone.
Details
Case reports in children suggest niacinamide 60-100 mg/kg/day reduces hepatic metabolism of primidone to phenobarbital, and reduces the overall clearance rate of primidone (14506); however, there is not enough data to determine the clinical significance of this potential interaction.
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Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
Details
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Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
Details
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Below is general information about the adverse effects of the known ingredients contained in the product NAD+. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, niacinamide is well tolerated in amounts typically found in food.
When used topically and orally in higher doses, niacinamide seems to be generally well tolerated.
Most Common Adverse Effects:
Orally: Dizziness, drowsiness, itching, gastrointestinal disturbances, headache, and rash.
Topically: Burning sensation, itching, and mild dermatitis.
Dermatologic ...Orally, large doses of niacinamide are associated with occasional reports of rashes, itching, and acanthosis nigricans (4880,11695,11697,14504,107709). Topically, application of niacinamide in a cream has been reported to cause a burning sensation, itching and pruritus, crusting, and mild dermatitis (93357,93360,110501,110498).
Endocrine ...Orally, niacinamide in high doses, 50 mg/kg daily, has been associated with modestly higher insulin requirements in patients with type 1 diabetes, when compared with taking niacinamide 25 mg/kg daily. Theoretically, high-dose niacinamide might increase insulin resistance, although to a lesser extent than niacin (4881,14512).
Gastrointestinal ...Orally, large doses of niacinamide can cause gastrointestinal disturbances including nausea, vomiting, heartburn, anorexia, epigastric pain, flatulence, and diarrhea (6243,11694,11695,11696,11697,107709).
Hematologic ...Orally, niacinamide supplementation might increase the risk for thrombocytopenia in patients undergoing hemodialysis (98940,107709). A meta-analysis of small clinical studies shows that taking niacinamide during hemodialysis to reduce phosphate levels is associated with a 2.8-fold increased risk for thrombocytopenia when compared with placebo. In one of the included studies, platelet levels returned to normal within 20 days after niacinamide discontinuation (98940).
Hepatic ...Orally, older reports of elevated liver function tests with high doses of niacinamide (3 grams or more daily) have raised concerns about liver toxicity. However, newer studies have not reported this concern; it is possible that some of these cases were due to contamination with niacin (4880,11694,11695,14503).
Neurologic/CNS ...Orally, large doses of niacinamide can cause dizziness, drowsiness, and headaches (11694,11695,11696,11697,107709).
General
...Orally and intravenously, ribose is generally well-tolerated for up to 1 month.
Most Common Adverse Effects:
Orally: Diarrhea, gastrointestinal discomfort, headache, hypoglycemia, nausea.
Intravenously: Hypoglycemia.
Endocrine
...Orally, ribose can decrease blood glucose levels (5667,92891).
In one pharmacokinetic study, fasting plasma glucose declined after single ribose doses of 2.5-10 grams. At all doses, serum glucose returned to near normal 2 hours post-administration but remained slightly below pre-dose levels for up to 5 hours. One case of symptomatic hypoglycemia 70 minutes post-dose was reported in a 53 kg female who took ribose 10 grams. The reaction was considered mild; however, specific blood glucose levels were not reported (92891).
Intravenously, ribose has been reported to cause hypoglycemia, increased serum insulin levels, and decreased serum phosphate (5650,5662,5663,5676).
Gastrointestinal ...Orally, ribose can cause diarrhea, gastrointestinal discomfort, and nausea (5664,5676,15218,92891). In one study, lowering the dose of ribose resolved the nausea (15218).
Neurologic/CNS ...Orally, ribose can cause headache (5664,92891). It has also been reported to cause a hyperanxious feeling, lightheadedness, increased appetite, and mild anxiety (15218). In one study, lowering the dose of ribose resolved the feeling of anxiety (15218).