Ingredients | Amount Per Serving |
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1000 mg |
Below is general information about the effectiveness of the known ingredients contained in the product Wintergreen Herb Powder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the effectiveness of periwinkle.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Wintergreen Herb Powder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally in very small amounts commonly found in foods. Wintergreen oil has Generally Recognized As Safe status (GRAS) in the US (4912) The highest concentration recommended for use as a food flavoring is 0.04% (6).
POSSIBLY SAFE ...when wintergreen leaf is used orally and appropriately in medicinal amounts (12). ...when wintergreen oil is used topically and appropriately (272).
POSSIBLY UNSAFE ...when wintergreen oil is used orally. Wintergreen oil contains large amounts of methyl salicylate, which is toxic (272). Ingesting as little as 6 mL can be lethal for an adult (6). One teaspoon (5 mL) of wintergreen oil is equivalent to approximately 7 grams of salicylate, or more than 20 adult aspirin tablets (6).
CHILDREN: LIKELY UNSAFE
when wintergreen oil is used orally.
Ingesting as little as 4 mL can be lethal to children (159). ...when wintergreen oil is used topically in children less than 2 years old (272).
PREGNANCY:
Insufficient reliable information is available; avoid using in amounts greater than those found in foods.
LACTATION: LIKELY UNSAFE
when used orally or topically.
Wintergreen products are likely toxic to nursing infants (19).
Below is general information about the interactions of the known ingredients contained in the product Wintergreen Herb Powder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, taking periwinkle may increase the effects of antihypertensive drugs due to the hypotensive activity of vincamine, a constituent of periwinkle (12,19).
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Using wintergreen oil topically in large amounts, with occlusive dressings, or for prolonged periods of time might increase the risk of additive salicylate toxicity when used with aspirin.
Details
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Using wintergreen oil topically might increase the effects and adverse effects of warfarin.
Details
Several case reports show that concomitant use of topical wintergreen oil-containing products and warfarin can increase INR and bleeding risk due to systemic absorption of the methyl salicylate contained in wintergreen oil (3811,6181). Topical analgesic gels, lotions, creams, ointments, liniments, and sprays can contain up to 55% methyl salicylate (6181).
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Below is general information about the adverse effects of the known ingredients contained in the product Wintergreen Herb Powder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...Periwinkle is generally regarded as unsafe for use. Orally, periwinkle can cause cytotoxic, neurologic, liver, and kidney damage due to its vinca alkaloid constituents (17). Periwinkle has also been reported to cause gastrointestinal complaints, skin flushing, and hypotension (18).
Cardiovascular ...Orally, large amounts of periwinkle can cause a severe drop in blood pressure (18).
Dermatologic ...Orally, periwinkle can cause skin flushing (18).
Gastrointestinal ...Orally, periwinkle can cause gastrointestinal complaints (18).
Hepatic ...Orally, periwinkle can cause liver damage due to its vinca alkaloid constituents (17).
Neurologic/CNS ...Orally, periwinkle can cause neurologic damage due to its vinca alkaloid constituents (17).
Renal ...Orally, periwinkle can cause kidney damage due to its vinca alkaloid constituents (17).
General
...Orally, wintergreen leaf seems to be well tolerated, while wintergreen oil may be unsafe.
Topically, wintergreen oil seems to be well tolerated.
Serious Adverse Effects (Rare):
Orally: Salicylate poisoning due to methyl salicylate in wintergreen oil.
Dermatologic ...Wintergreen oil can cause contact dermatitis, which can be irritant or allergic in nature (18,3811,112157). When the oil is applied topically it should not be covered with an occlusive dressing because this could result in absorption of toxic amounts of methyl salicylate (272).
Gastrointestinal ...Orally, wintergreen oil can result in symptoms of salicylate poisoning, including nausea, vomiting, diarrhea, and stomach pain (272). Wintergreen causes gastrointestinal irritation (19).
Neurologic/CNS ...Orally, wintergreen oil can result in symptoms of salicylate poisoning, including headache, tinnitus, and confusion (272).