Ingredients | Amount Per Serving |
---|---|
(Schizonepeta tenuifolia )
(herb)
(Jing Jie, Extraction rate: about 1/3-4 (up to 333 mg of dry raw material per 1 ml of extract).)
|
983 mg |
Alcohol, Water, Glycerin
Below is general information about the effectiveness of the known ingredients contained in the product Jing Jie. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Jing Jie. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY UNSAFE ...when used orally in excessive amounts. Schizonepeta contains pulegone, a known hepatotoxin (12620,12626).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Jing Jie. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 1A2 (94787). Theoretically, schizonepeta might increase the effects and side effects of CYP1A2 substrates.
Details
Some substrates of CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
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Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 2D6 (94787). Theoretically, schizonepeta might increase the effects and side effects of CYP2D6 substrates.
Details
Some substrates of CYP2D6 include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), and others.
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Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 2E1 (94787). Theoretically, schizonepeta might increase the effects and side effects of CYP2E1 substrates.
Details
Some substrates of CYP2E1 include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), and methoxyflurane (Penthrane).
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Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4 (94787). Theoretically, schizonepeta might decrease the effects of CYP3A4 substrates.
Details
Some substrates of CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and numerous others.
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Below is general information about the adverse effects of the known ingredients contained in the product Jing Jie. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...There is currently a limited amount of information available about the adverse effects of schizonepeta.
Orally, a specific combination product (Zemaphyte, Phytopharm Plc) containing schizonepeta and numerous other ingredients has been reported to cause nausea, vomiting, colic, dyspepsia, dizziness, headache, and hair loss (12627,12630). However, it is unclear if these effects are due to schizonepeta or the other ingredients.
High doses of schizonepeta may be hepatotoxic due to its pulegone constituent (12620,12626).
Gastrointestinal ...Orally, a specific combination product (Zemaphyte, Phytopharm Plc) containing schizonepeta and numerous other ingredients has been reported to cause nausea, vomiting, colic, and dyspepsia (12627,12630). However, it is unclear if these effects are due to schizonepeta or the other ingredients.
Hepatic ...Schizonepeta contains pulegone, a hepatotoxin. When taken orally in high doses, schizonepeta may be hepatotoxic due to this constituent (12620,12626).
Neurologic/CNS ...Orally, a specific combination product (Zemaphyte, Phytopharm Plc) containing schizonepeta and numerous other ingredients has been reported to cause dizziness and headache (12627,12630). However, it is unclear if these effects are due to schizonepeta or the other ingredients.