RNA 125 & DNA 125 [Discontinued] by GNC

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Athletic performance. A small clinical trial in healthy men shows that taking sublingual nucleotides 50 mg daily for 14 days increases time to exhaustion during an exercise test by 12 seconds when compared with placebo. There was no effect on heart rate, speed, or perceived exertion (100724). Another small clinical trial in healthy men and women shows that taking 2 capsules twice daily of a supplement (NuBound, Nu Science Laboratories, Inc.) containing nucleotides, amino acids, B vitamins, and prebiotics reduces the time for return to baseline isometric force generation following a resistance exercise protocol by 24 hours when compared with placebo. However, there was no effect on jump peak power (100725). It is not clear if this effect is due to nucleotides, the other ingredients, or the combination.
• Burns. Preliminary clinical research shows that taking RNA and DNA enterally doesn't seem to improve outcomes in burn patients when compared with standard nutritional formulas (5535).
• Irritable bowel syndrome (IBS). A small clinical trial in adults with IBS shows that taking a specific product containing RNA, nucleotides, and other ingredients (IntestAidIB) 500 mg three times daily for 8 weeks modestly improves symptoms of IBS, including abdominal pain, urgency, and incomplete evacuation, when compared with placebo. However, the large effect seen in the placebo group limits the validity of these findings Also, taking this specific product did not improve diarrhea or constipation when compared with placebo (100723). Furthermore, it is not clear if these effects are due to RNA, the other ingredients, or the combination.
• Postoperative infection. Preliminary clinical research shows that administering enteral nutrition supplemented with RNA, eicosapentaenoic acid, and L-arginine during the postoperative period reduces the percentage of patients experiencing postoperative infectious complications and shortens the duration of hospitalization by about 4 days when compared with standard enteral nutrition (5531). It is not clear if this effect is due to RNA, the other ingredients, or the combination. More evidence is needed to rate RNA and DNA for these uses.

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LIKELY SAFE ...when RNA and DNA are consumed in food. ...when RNA is used in enteral nutrition along with omega-3 fatty acids and L-arginine (5531,5533,5534,5535,5536,7819).

POSSIBLY SAFE ...when RNA is injected subcutaneously (5538) . ..when nucleotides are used sublingually at doses of up to 50 mg daily for up to 14 days (100724,100727). There is insufficient reliable information available about the safety of RNA/DNA supplement combinations.

CHILDREN: LIKELY SAFE
when infant formulas contain nucleotide supplements (5900). Infant formulas containing RNA or DNA at a dose of up 72 mg/L for up to the first 12 months of life have been used with apparent safety (100729,100730,100731).

PREGNANCY AND LACTATION: POSSIBLY UNSAFE
when used orally as supplements. Some evidence suggests some orally ingested DNA might cross the placenta and be mutagenic (5539).

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General ...Orally, RNA and DNA are well tolerated when consumed in food or enteral nutrition (5531,5533,5534,5535,5536,7819). Nucleotides seem to be well tolerated when consumed in medicinal amounts for up to 14 days. No adverse effects have been reported. Subcutaneously, RNA can cause itching, redness, and swelling at the injection site (5538).

Dermatologic ...Subcutaneously, an injection of RNA can cause itching, redness, and swelling at the injection site. In one review, these reactions occurred in 3 out of 83 patients (5538).

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